Abstract
All current drugs approved to treat schizophrenia appear to exert their antipsychotic effects through blocking the dopamine D2 receptor. Recent meta-analyses and comparative efficacy studies indicate marginal differences in efficacy of newer atypical antipsychotics and the older drugs, and little effects on negative and cognitive symptoms. This review integrates findings from postmortem, imaging, and drug-challenge studies to elucidate a corticolimbic "pathologic circuit" in schizophrenia that may be particularly relevant to the negative symptoms and cognitive impairments of schizophrenia. Potential sites for pharmacologic intervention targeting glutatatergic, GABAergic, and cholinergic neurotransmission to treat these symptoms of schizophrenia are discussed.
| Translated title of the contribution | Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 359-382 |
| Number of pages | 24 |
| Journal | Dialogues in Clinical Neuroscience |
| Volume | 12 |
| Issue number | 3 |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- Glutamate
- Metabotropic glutamate receptor
- N-methyl-D-aspartate receptor
- Nicotinic acetylcholine receptor
- γ-aminobutyric acid