TY - JOUR
T1 - Biocatalytic plastics as active and stable materials for biotransformations
AU - Wang, Ping
AU - Sergeeva, Maria V.
AU - Lim, Lilian
AU - Dordick, Jonathan S.
PY - 1997/8
Y1 - 1997/8
N2 - Enzyme-containing polymeric materials have been developed that have high activity and stability in both aqueous and organic media. These biocatalytic plastics, containing α-chymotrypsin and subtilisin Carlsberg, can contain up to 50% (w/w) total protein in plastic materials such as poly(methyl methacrylate, styrene, vinyl acetate, and ethyl vinyl ether). The activation achieved in organic solvents by incorporating proteases in plastic matrices allows for the efficient synthesis of peptides, and sugar and nucleoside esters. The marriage of enzyme technology with polymer chemistry opens up an array of unique applications for plastic enzymes, including active and stable biocatalysts in paints, coatings, resins, foams, and beads, as well as membranes, fibers, and tubings.
AB - Enzyme-containing polymeric materials have been developed that have high activity and stability in both aqueous and organic media. These biocatalytic plastics, containing α-chymotrypsin and subtilisin Carlsberg, can contain up to 50% (w/w) total protein in plastic materials such as poly(methyl methacrylate, styrene, vinyl acetate, and ethyl vinyl ether). The activation achieved in organic solvents by incorporating proteases in plastic matrices allows for the efficient synthesis of peptides, and sugar and nucleoside esters. The marriage of enzyme technology with polymer chemistry opens up an array of unique applications for plastic enzymes, including active and stable biocatalysts in paints, coatings, resins, foams, and beads, as well as membranes, fibers, and tubings.
KW - Biocatalytic plastics
KW - Enzyme stabilization
KW - Organic solvents
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U2 - 10.1038/nbt0897-789
DO - 10.1038/nbt0897-789
M3 - Article
C2 - 9255796
AN - SCOPUS:0030762554
VL - 15
SP - 789
EP - 793
JO - Biotechnology
JF - Biotechnology
SN - 1087-0156
IS - 8
ER -