Biocompatible characteristics of sulfobetaine-containing brush polymers

Jin Chul Kim, Mihee Kim, Jungwoon Jung, Heesoo Kim, Ik Jung Kim, Jung Ran Kim, Moonhor Ree

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A series of well-defined brush polymers, poly(oxy(11-(3- sulfonylpropyltrimethyl-glycinyl)undecylesterthiomethyl) ethylene-co-oxy(n- dodecylthio-methyl)ethylene)s (PECH-DMAPSm, where m is the mol% of the DMAPS [sulfobetaine] end group) were synthesized. The thermal properties and phase transitions of these polymers were investigated. The polymers were thermally stable up to 185 °C and were found to form favorably into multibilayer structures, always providing hydrophilic, zwitterionic sulfobetaine end groups at the film surface. Because of the presence of these sulfobetaine groups at the surface, the polymer films promoted HEp-2 cell adhesion and revealed biocompatibility in mice but significantly suppressed protein adsorption. These results collectively indicate that the sulfobetaine-containing brush polymers are suitable for use in biomedical applications, including medical devices and biosensors that require biocompatibility.

Original languageEnglish (US)
Pages (from-to)746-753
Number of pages8
JournalMacromolecular Research
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2012

Keywords

  • Biocompatibility
  • Brush polymer
  • Cell adhesion
  • Protein adsorption
  • Self-assembly
  • Sulfobetaine
  • Water contact angle
  • Water sorption

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