Biodemographic trajectories of longevity

James W. Vaupel; James R. Carey; Kaare Christensen; Thomas E. Johnson; Anatoli I. Yashin; Niels V. Holm; Ivan A. Iachine; Väinö Kannisto; Aziz A. Khazaeli; Pablo Liedo; Valter D. Longo; Yi Zeng; Kenneth G. Manton; James W. Curtsinger

doi:10.1126/science.280.5365.855

Biodemographic trajectories of longevity

James W. Vaupel, James R. Carey, Kaare Christensen, Thomas E. Johnson, Anatoli I. Yashin, Niels V. Holm, Ivan A. Iachine, Väinö Kannisto, Aziz A. Khazaeli, Pablo Liedo, Valter D. Longo, Yi Zeng, Kenneth G. Manton, James W. Curtsinger

Ecology, Evolution and Behavior

Research output: Contribution to journal › Review article › peer-review

780 Scopus citations

Abstract

Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights - concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality - offer clues and suggest research on the failure of complicated systems, on new demographic equation for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explications of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.

Original language	English (US)
Pages (from-to)	855-860
Number of pages	6
Journal	Science
Volume	280
Issue number	5365
DOIs	https://doi.org/10.1126/science.280.5365.855
State	Published - May 8 1998

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title = "Biodemographic trajectories of longevity",

abstract = "Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights - concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality - offer clues and suggest research on the failure of complicated systems, on new demographic equation for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explications of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.",

author = "Vaupel, {James W.} and Carey, {James R.} and Kaare Christensen and Johnson, {Thomas E.} and Yashin, {Anatoli I.} and Holm, {Niels V.} and Iachine, {Ivan A.} and V{\"a}in{\"o} Kannisto and Khazaeli, {Aziz A.} and Pablo Liedo and Longo, {Valter D.} and Yi Zeng and Manton, {Kenneth G.} and Curtsinger, {James W.}",

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AU - Vaupel, James W.

AU - Carey, James R.

AU - Christensen, Kaare

AU - Johnson, Thomas E.

AU - Yashin, Anatoli I.

AU - Holm, Niels V.

AU - Iachine, Ivan A.

AU - Kannisto, Väinö

AU - Khazaeli, Aziz A.

AU - Liedo, Pablo

AU - Longo, Valter D.

AU - Zeng, Yi

AU - Manton, Kenneth G.

AU - Curtsinger, James W.

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AB - Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights - concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality - offer clues and suggest research on the failure of complicated systems, on new demographic equation for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explications of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.

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Biodemographic trajectories of longevity

Abstract

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