Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles

Yuanpeng Li; Ying Jing; Xiaofeng Yao; Balasubramanian Srinivasan; Yunhao Xu; Chengguo Xing; Jian Ping Wang

doi:10.1109/IEMBS.2009.5332479

Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles

Yuanpeng Li, Ying Jing, Xiaofeng Yao, Balasubramanian Srinivasan, Yunhao Xu, Chengguo Xing, Jian Ping Wang

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Abstract

In this paper, we present a ultra high sensitive (Zeptomole, 10 ^-21) technique to enable the detection of any potential low abundance biomarkers. We demonstrated for the first time the detection of sub 13nm high-moment magnetic nanoparticle and the implementation of a novel magnetoresistive (GMR) biosensor concept with higher sensitivity and 10 times lower external field in real biomarker sensing schemes. A potential lung cancer biomarker, interleukin-6 (IL-6), was successfully detected with extremely low concentration (as few as only 200 pieces of IL-6). Together with other features of GMR sensor systems like low-cost, portability, easy-to-use, our demonstrated device may lead to future family-based personalized medicine for cancer prevention.

Original language	English (US)
Pages (from-to)	5432-5435
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
DOIs	https://doi.org/10.1109/IEMBS.2009.5332479
State	Published - 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

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Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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Li, Y., Jing, Y., Yao, X., Srinivasan, B., Xu, Y., Xing, C., & Wang, J. P. (2009). Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 5432-5435. https://doi.org/10.1109/IEMBS.2009.5332479

Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles. / Li, Yuanpeng; Jing, Ying; Yao, Xiaofeng et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009, p. 5432-5435.

Research output: Contribution to journal › Article › peer-review

Li, Y, Jing, Y, Yao, X, Srinivasan, B, Xu, Y, Xing, C & Wang, JP 2009, 'Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, pp. 5432-5435. https://doi.org/10.1109/IEMBS.2009.5332479

Li Y, Jing Y, Yao X, Srinivasan B, Xu Y, Xing C et al. Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2009;5432-5435. doi: 10.1109/IEMBS.2009.5332479

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Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles

Abstract

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