TY - JOUR
T1 - Biomarkers of vitamin B-12 status in NHANES
T2 - A roundtable summary
AU - Yetley, Elizabeth A.
AU - Pfeiffer, Christine M.
AU - Phinney, Karen W.
AU - Bailey, Regan L.
AU - Blackmore, Sheena
AU - Bock, Jay L.
AU - Brody, Lawrence C.
AU - Carmel, Ralph
AU - Curtin, L. Randy
AU - Durazo-Arvizu, Ramón A.
AU - Eckfeldt, John H
AU - Green, Ralph
AU - Gregory, Jesse F.
AU - Hoofnagle, Andrew N.
AU - Jacobsen, Donald W.
AU - Jacques, Paul F.
AU - Lacher, David A.
AU - Molloy, Anne M.
AU - Massaro, Joseph
AU - Mills, James L.
AU - Nexo, Ebba
AU - Rader, Jeanne I.
AU - Selhub, Jacob
AU - Sempos, Christopher
AU - Shane, Barry
AU - Stabler, Sally
AU - Stover, Patrick
AU - Tamura, Tsunenobu
AU - Tedstone, Alison
AU - Thorpe, Susan J.
AU - Coates, Paul M.
AU - Johnson, Clifford L.
AU - Picciano, Mary Frances
PY - 2011/7/1
Y1 - 2011/7/1
N2 - A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12 - related biomarkers after 2006. The roundtable reviewed 3 biomarkers of vitamin B-12 status used in past NHANES - serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy) - and discussed the potential utility of measuring holotranscobalamin (holoTC) for future NHANES. Theroundtable focused on public health considerations and the quality of the measurement procedures and reference methods and materials that past NHANES used or that are available for future NHANES. Roundtable members supported reinstating vitamin B-12 status measures in NHANES. They noted evolving concerns and uncertainties regarding whether subclinical (mild, asymptomatic) vitamin B-12 deficiency is a public health concern. They identified the need for evidence from clinical trials to address causal relations between subclinical vitamin B-12 deficiency and adverse health outcomes as well as appropriate cutoffs for interpreting vitamin B-12 - related biomarkers. Theyagreed thatproblems with sensitivityandspecificity of individual biomarkers underscore the need for including at least one biomarker of circulating vitamin B-12 (serum vitamin B-12 or holoTC) and one functional biomarker (MMA or tHcy) in NHANES. The inclusion of both serum vitamin B-12 and plasma MMA, which have been associated with cognitive dysfunction and anemia in NHANES and in other population-based studies, was preferable to provide continuity with past NHANES. Reliable measurement procedures are available, and National Institute of Standards and Technology reference materials are available or in development for serum vitamin B-12 and MMA.
AB - A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12 - related biomarkers after 2006. The roundtable reviewed 3 biomarkers of vitamin B-12 status used in past NHANES - serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy) - and discussed the potential utility of measuring holotranscobalamin (holoTC) for future NHANES. Theroundtable focused on public health considerations and the quality of the measurement procedures and reference methods and materials that past NHANES used or that are available for future NHANES. Roundtable members supported reinstating vitamin B-12 status measures in NHANES. They noted evolving concerns and uncertainties regarding whether subclinical (mild, asymptomatic) vitamin B-12 deficiency is a public health concern. They identified the need for evidence from clinical trials to address causal relations between subclinical vitamin B-12 deficiency and adverse health outcomes as well as appropriate cutoffs for interpreting vitamin B-12 - related biomarkers. Theyagreed thatproblems with sensitivityandspecificity of individual biomarkers underscore the need for including at least one biomarker of circulating vitamin B-12 (serum vitamin B-12 or holoTC) and one functional biomarker (MMA or tHcy) in NHANES. The inclusion of both serum vitamin B-12 and plasma MMA, which have been associated with cognitive dysfunction and anemia in NHANES and in other population-based studies, was preferable to provide continuity with past NHANES. Reliable measurement procedures are available, and National Institute of Standards and Technology reference materials are available or in development for serum vitamin B-12 and MMA.
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U2 - 10.3945/ajcn.111.013243
DO - 10.3945/ajcn.111.013243
M3 - Article
C2 - 21593512
AN - SCOPUS:79959470408
SN - 0002-9165
VL - 94
SP - 313S-321S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -