Biomimetic fabrication and characterization of collagen/strontium hydroxyapatite nanocomposite

Yipin Qi, Sui Mai, Zhou Ye, Conrado Aparicio

Research output: Contribution to journalArticlepeer-review


Strontium-releasing bioactive materials have attracted considerable attention for patients with osteoporotic bone defects due to its ability to stimulate bone formation and decrease bone resorption. In the present study, type I collagen/strontium hydroxyapatite nanocomposite (cSrHA) was fabricated via a non-classical biomimetic mineralization pathway. Mineralized collagen fibrils with nanosized SrHA embedded in intrafibrillar interstices were obtained using poly(acrylic acid) as a biomimetic mineralizing director. The resultant nanocomposite was characterized by SEM, TEM, EDS, ATR-FTIR, XRD and TGA. cSrHA displayed morphologies, nanostructures and characteristics similar to those of natural hard tissue and calcium hydroxyapatite-mineralized collagen (cCaHA), indicating its potential value as a biofunctional material for bone engineering.

Original languageEnglish (US)
Article number127982
JournalMaterials Letters
StatePublished - Sep 1 2020


  • Biomimetic
  • Nanocomposites
  • Nanocrystals
  • Strontium hydroxyapatite
  • Type I collagen

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