Biosensor based on layer by layer deposited phosphorene nanoparticles for liver cancer detection

Jungyoon Kim; Shota Sando; Tianhong Cui

doi:10.1115/IMECE2017-71022

Biosensor based on layer by layer deposited phosphorene nanoparticles for liver cancer detection

Jungyoon Kim, Shota Sando, Tianhong Cui

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Properties of phosphorene are intensively researched by many research groups since it was discovered in 2014. This new 2D material has a direct band-gap, depending on the number of layers (0.3 eV for bulk to 2.0 eV for monolayer) similar to MoS₂. In this paper, we report layer-by-layer (LbL) deposition method to deposit a few layers of phosphorene film on the substrate, and successfully fabricate phosphorene field effect transistor (FET) with LbL black phosphorus (BP) film. By using the FET characteristics of the device, we fabricate biosensors with Poly-L-lysine (PLL) linker molecules and Alpha-fetoprotein (AFP) antibody to detect different concentration of AFP antigen (0.1 ppb to 1 ppm). The results indicate that BP can be a promising material for biosensing applications.

Original language	English (US)
Title of host publication	Advanced Manufacturing
Publisher	American Society of Mechanical Engineers (ASME)
ISBN (Electronic)	9780791858356
DOIs	https://doi.org/10.1115/IMECE2017-71022
State	Published - 2017
Event	ASME 2017 International Mechanical Engineering Congress and Exposition, IMECE 2017 - Tampa, United States Duration: Nov 3 2017 → Nov 9 2017

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	2

Other

Other	ASME 2017 International Mechanical Engineering Congress and Exposition, IMECE 2017
Country/Territory	United States
City	Tampa
Period	11/3/17 → 11/9/17

Bibliographical note

Funding Information:
The authors acknowledge the assistance of fabrication and characterization from Minnesota Nano Center and the Characterization Facility at the University of Minnesota. The authors also thank Handol Lee for the NTA measurement and discussions.

Publisher Copyright:
Copyright © 2017 ASME.

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Biosensor based on layer by layer deposited phosphorene nanoparticles for liver cancer detection. / Kim, Jungyoon; Sando, Shota; Cui, Tianhong.
Advanced Manufacturing. American Society of Mechanical Engineers (ASME), 2017. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, J, Sando, S & Cui, T 2017, Biosensor based on layer by layer deposited phosphorene nanoparticles for liver cancer detection. in Advanced Manufacturing. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 2, American Society of Mechanical Engineers (ASME), ASME 2017 International Mechanical Engineering Congress and Exposition, IMECE 2017, Tampa, United States, 11/3/17. https://doi.org/10.1115/IMECE2017-71022

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abstract = "Properties of phosphorene are intensively researched by many research groups since it was discovered in 2014. This new 2D material has a direct band-gap, depending on the number of layers (0.3 eV for bulk to 2.0 eV for monolayer) similar to MoS2. In this paper, we report layer-by-layer (LbL) deposition method to deposit a few layers of phosphorene film on the substrate, and successfully fabricate phosphorene field effect transistor (FET) with LbL black phosphorus (BP) film. By using the FET characteristics of the device, we fabricate biosensors with Poly-L-lysine (PLL) linker molecules and Alpha-fetoprotein (AFP) antibody to detect different concentration of AFP antigen (0.1 ppb to 1 ppm). The results indicate that BP can be a promising material for biosensing applications.",

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note = "Funding Information: The authors acknowledge the assistance of fabrication and characterization from Minnesota Nano Center and the Characterization Facility at the University of Minnesota. The authors also thank Handol Lee for the NTA measurement and discussions. Publisher Copyright: Copyright {\textcopyright} 2017 ASME.; ASME 2017 International Mechanical Engineering Congress and Exposition, IMECE 2017 ; Conference date: 03-11-2017 Through 09-11-2017",

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AB - Properties of phosphorene are intensively researched by many research groups since it was discovered in 2014. This new 2D material has a direct band-gap, depending on the number of layers (0.3 eV for bulk to 2.0 eV for monolayer) similar to MoS2. In this paper, we report layer-by-layer (LbL) deposition method to deposit a few layers of phosphorene film on the substrate, and successfully fabricate phosphorene field effect transistor (FET) with LbL black phosphorus (BP) film. By using the FET characteristics of the device, we fabricate biosensors with Poly-L-lysine (PLL) linker molecules and Alpha-fetoprotein (AFP) antibody to detect different concentration of AFP antigen (0.1 ppb to 1 ppm). The results indicate that BP can be a promising material for biosensing applications.

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Biosensor based on layer by layer deposited phosphorene nanoparticles for liver cancer detection

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