TY - JOUR
T1 - Bioseparations, especially by hollow fibers
AU - Cussler, E. L.
PY - 1989
Y1 - 1989
N2 - Downstream processing in biotechnology is best idealized as a four step process: removal of insolubles, isolation, purification, and polishing. The first and last steps are relatively easily achieved; the isolation and purification steps include most of the potential problems. While purification has often been presumed the most difficult, isolation may involve the greatest cost, presumably because it involves getting a small volume of concentrate from a large volume of feed. Both purification and isolation can sometimes use hollow fibers for extraction and chromatography.
AB - Downstream processing in biotechnology is best idealized as a four step process: removal of insolubles, isolation, purification, and polishing. The first and last steps are relatively easily achieved; the isolation and purification steps include most of the potential problems. While purification has often been presumed the most difficult, isolation may involve the greatest cost, presumably because it involves getting a small volume of concentrate from a large volume of feed. Both purification and isolation can sometimes use hollow fibers for extraction and chromatography.
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U2 - 10.1002/bbpc.19890930904
DO - 10.1002/bbpc.19890930904
M3 - Conference article
AN - SCOPUS:0024733434
SN - 0005-9021
VL - 93
SP - 944
EP - 948
JO - Berichte der Bunsengesellschaft/Physical Chemistry Chemical Physics
JF - Berichte der Bunsengesellschaft/Physical Chemistry Chemical Physics
IS - 9
T2 - Physico-Chemical Separation Processes in Biotechnology
Y2 - 13 March 1989 through 15 March 1989
ER -