[Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent: Application toward One-Flask Transformations of Carboxylic Acids to Amides

Jonathan M. White; Ashok Rao Tunoori; Brandon J. Turunen; Gunda I. Georg

doi:10.1021/jo035658k

[Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent: Application toward One-Flask Transformations of Carboxylic Acids to Amides

Jonathan M. White, Ashok Rao Tunoori, Brandon J. Turunen, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.

Original language	English (US)
Pages (from-to)	2573-2576
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	69
Issue number	7
DOIs	https://doi.org/10.1021/jo035658k
State	Published - Apr 2 2004

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AU - Georg, Gunda I.

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[Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent: Application toward One-Flask Transformations of Carboxylic Acids to Amides

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