Blood endothelial cells: Utility from ambiguity

Robert P. Hebbel

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


In the mid-1990s, my research group began to devise a method to establish endothelial cell cultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity of endothelial biology. The initial work, published in the JCI in 2000, described the method enabling successful attainment of blood outgrowth endothelial cells (BOEC). Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a putative endothelial progenitor. Our subsequent experimental work focused upon practical applications of BOEC: their use for gene therapy, tissue engineering, assessment of mutant gene effect, and discovery of heterogeneity in endothelial biology.

Original languageEnglish (US)
Pages (from-to)1613-1615
Number of pages3
JournalJournal of Clinical Investigation
Issue number5
StatePublished - May 1 2017

Bibliographical note

Funding Information:
The work mentioned herein was funded by: the National Institutes of Health (HL55174, HL62931, DK56326, HL70460, HL71269, HL076540, and HL55552); by Octagen Corporation, COR Therapeutics and Millennium Pharmaceuticals; and by the National Hemophilia Foundation


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