The relationship of baseline characteristics to serum cholesterol at baseline (CHL47) when aged 16-25 (mean 20.5) yr and at 32-yr follow-up (CHL79) was assessed in 162 men. Mean CHL rose over the follow-up period. CHL47 predicted CHL79 (r = 0.61, p < 0.001) but not CHL79-CHL47. The mean (± SD) weight change (DW) was 12.0 kg (± 26.0 kg). DW was not significantly related to CHL47, but was independently related to CHL79-CHL47 (r = 0.30, p < 0.001). Age, height, DW, any of 7 measures of baseline obesity and CHL47 predicted CHL79 with R2 of 0.40 and CHL79-CHL47 with R2 of 0.37. Thus, weight change but not baseline relative weight was a determinant of serum cholesterol change from youth to middle age. There was strong tracking of serum cholesterol over this period.
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*This work was supported by NIH National Heart, Lung and Blood Institute Grant No. HL23482, Minnesota Medical Foundation and by Research Career Development Award 1 K04 HLO0329.