Body building: Regulation of shape and size by PI3K/TOR signaling during development

Thomas P. Neufeld

doi:10.1016/j.mod.2003.07.003

Body building: Regulation of shape and size by PI3K/TOR signaling during development

Thomas P. Neufeld

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth.

Original language	English (US)
Pages (from-to)	1283-1296
Number of pages	14
Journal	Mechanisms of Development
Volume	120
Issue number	11
DOIs	https://doi.org/10.1016/j.mod.2003.07.003
State	Published - Nov 2003

Keywords

Autophagy
Cell growth
Drosophila
Morphogenesis
Phosphatidylinositol 3-kinase
Spindle orientation
Target of rapamycin

Access

10.1016/j.mod.2003.07.003

OpenUrl availability

Full text

Cite this

@article{1e834548ce974af9bde327d22bc3de59,

title = "Body building: Regulation of shape and size by PI3K/TOR signaling during development",

abstract = "Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth.",

keywords = "Autophagy, Cell growth, Drosophila, Morphogenesis, Phosphatidylinositol 3-kinase, Spindle orientation, Target of rapamycin",

author = "Neufeld, {Thomas P.}",

year = "2003",

month = nov,

doi = "10.1016/j.mod.2003.07.003",

language = "English (US)",

volume = "120",

pages = "1283--1296",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd",

number = "11",

}

TY - JOUR

T1 - Body building

T2 - Regulation of shape and size by PI3K/TOR signaling during development

AU - Neufeld, Thomas P.

PY - 2003/11

Y1 - 2003/11

N2 - Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth.

AB - Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth.

KW - Autophagy

KW - Cell growth

KW - Drosophila

KW - Morphogenesis

KW - Phosphatidylinositol 3-kinase

KW - Spindle orientation

KW - Target of rapamycin

UR - http://www.scopus.com/inward/record.url?scp=0242664808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242664808&partnerID=8YFLogxK

U2 - 10.1016/j.mod.2003.07.003

DO - 10.1016/j.mod.2003.07.003

M3 - Review article

C2 - 14623438

AN - SCOPUS:0242664808

SN - 0925-4773

VL - 120

SP - 1283

EP - 1296

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 11

ER -

Body building: Regulation of shape and size by PI3K/TOR signaling during development

Abstract

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this