Bone formation on carbon nanotube composite

Mrinal Bhattacharya; Patcharaporn Wutticharoenmongkol-Thitiwongsawet; Darryl T. Hamamoto; Dongjin Lee; Tianhong Cui; Hari S. Prasad; Mansur Ahmad

doi:10.1002/jbm.a.32958

Bone formation on carbon nanotube composite

Mrinal Bhattacharya, Patcharaporn Wutticharoenmongkol-Thitiwongsawet, Darryl T. Hamamoto, Dongjin Lee, Tianhong Cui, Hari S. Prasad, Mansur Ahmad

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Abstract

The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Journal of Biomedical Materials Research - Part A
Volume	96 A
Issue number	1
DOIs	https://doi.org/10.1002/jbm.a.32958
State	Published - Jan 2011

Keywords

carbon nanotube
critical sized defect
mineralization
osteoblast
titanium

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AU - Lee, Dongjin

AU - Cui, Tianhong

AU - Prasad, Hari S.

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Bone formation on carbon nanotube composite

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