(-)-Botryodiplodin, a unique ribose-analog toxin

W. Thomas Shier; Hamed K. Abbas; Richard E. Baird; Mohammad Ramezani; Gabriel L. Sciumbato

doi:10.1080/15569540701741866

(-)-Botryodiplodin, a unique ribose-analog toxin

W. Thomas Shier, Hamed K. Abbas, Richard E. Baird, Mohammad Ramezani, Gabriel L. Sciumbato

Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Frequently toxins are structural analogs of essential metabolites, acting by interfering with normal metabolism. Because ribose derivatives play critical roles in information storage, energy currency, and photosynthesis, ribose should provide the basis for a toxic analog mechanism. The only known simple ribose-analog toxin, (-)-botryodiplodin, exhibits anticancer, antibacterial, antifungal, phytotoxic, mitogenic, and antifertility activities, and may play a role in plant diseases. Unusual structural properties allow oligomerization of (-)-botryodiplodin to pigments and cross-linking agents, which may be responsible for some of its biological activities, but there is no evidence that (-)-botryodiplodin or any other known toxin acts by a ribose-analog mechanism.

Original language	English (US)
Pages (from-to)	343-386
Number of pages	44
Journal	Toxin Reviews
Volume	26
Issue number	4
DOIs	https://doi.org/10.1080/15569540701741866
State	Published - Oct 2007

Bibliographical note

Funding Information:
This work was supported in part by the Mississippi Soybean Promotion Board and the Mississippi State University Research Initiatives grants program.

Keywords

Anti-cancer agents
Botryodiplodin
Charcoal rot disease
Cross-linking agents
Phaseolinone
Ribose-analog toxin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "(-)-Botryodiplodin, a unique ribose-analog toxin",

abstract = "Frequently toxins are structural analogs of essential metabolites, acting by interfering with normal metabolism. Because ribose derivatives play critical roles in information storage, energy currency, and photosynthesis, ribose should provide the basis for a toxic analog mechanism. The only known simple ribose-analog toxin, (-)-botryodiplodin, exhibits anticancer, antibacterial, antifungal, phytotoxic, mitogenic, and antifertility activities, and may play a role in plant diseases. Unusual structural properties allow oligomerization of (-)-botryodiplodin to pigments and cross-linking agents, which may be responsible for some of its biological activities, but there is no evidence that (-)-botryodiplodin or any other known toxin acts by a ribose-analog mechanism.",

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author = "Shier, {W. Thomas} and Abbas, {Hamed K.} and Baird, {Richard E.} and Mohammad Ramezani and Sciumbato, {Gabriel L.}",

note = "Funding Information: This work was supported in part by the Mississippi Soybean Promotion Board and the Mississippi State University Research Initiatives grants program.",

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AU - Abbas, Hamed K.

AU - Baird, Richard E.

AU - Ramezani, Mohammad

AU - Sciumbato, Gabriel L.

N1 - Funding Information: This work was supported in part by the Mississippi Soybean Promotion Board and the Mississippi State University Research Initiatives grants program.

PY - 2007/10

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N2 - Frequently toxins are structural analogs of essential metabolites, acting by interfering with normal metabolism. Because ribose derivatives play critical roles in information storage, energy currency, and photosynthesis, ribose should provide the basis for a toxic analog mechanism. The only known simple ribose-analog toxin, (-)-botryodiplodin, exhibits anticancer, antibacterial, antifungal, phytotoxic, mitogenic, and antifertility activities, and may play a role in plant diseases. Unusual structural properties allow oligomerization of (-)-botryodiplodin to pigments and cross-linking agents, which may be responsible for some of its biological activities, but there is no evidence that (-)-botryodiplodin or any other known toxin acts by a ribose-analog mechanism.

AB - Frequently toxins are structural analogs of essential metabolites, acting by interfering with normal metabolism. Because ribose derivatives play critical roles in information storage, energy currency, and photosynthesis, ribose should provide the basis for a toxic analog mechanism. The only known simple ribose-analog toxin, (-)-botryodiplodin, exhibits anticancer, antibacterial, antifungal, phytotoxic, mitogenic, and antifertility activities, and may play a role in plant diseases. Unusual structural properties allow oligomerization of (-)-botryodiplodin to pigments and cross-linking agents, which may be responsible for some of its biological activities, but there is no evidence that (-)-botryodiplodin or any other known toxin acts by a ribose-analog mechanism.

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KW - Botryodiplodin

KW - Charcoal rot disease

KW - Cross-linking agents

KW - Phaseolinone

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(-)-Botryodiplodin, a unique ribose-analog toxin

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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