Brain mapping biomarkers of socio-emotional processing in schizophrenia

Stephan F. Taylor, Angus W. MacDonald

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative has formed with the expressed intent of identifying constructs and paradigms that would identify biomarkers of psychosis. The manipulation of these biomarkers would serve as targets for treatment interventions. The second phase of CNTRICS consisted of critical discussions evaluating brain mapping (functional neuroimaging and brain electrical activity) paradigms as biomarkers to measure specific constructs. Among the constructs identified in, CNTRICS I was socio-emotional processing, specifically focused on affect recognition. Here, we provide a critical appraisal of the ability of candidate socio-emotional tasks to identify putative biomarkers and recommendations for future directions in this rapidly moving research domain.

    Original languageEnglish (US)
    Pages (from-to)73-80
    Number of pages8
    JournalSchizophrenia bulletin
    Volume38
    Issue number1
    DOIs
    StatePublished - Jan 2012

    Keywords

    • ERP
    • amygdala
    • emotion
    • fMRI
    • social

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