Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Dejene M. Tufa, Fareed Ahmad, Debanjana Chatterjee, Gerrit Ahrenstorf, Reinhold E. Schmidt, Roland Jacobs

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume73
Issue number1
DOIs
StatePublished - Sep 1 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • HIV
  • IL-1β
  • slanDCs

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