Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Dejene M. Tufa; Fareed Ahmad; Debanjana Chatterjee; Gerrit Ahrenstorf; Reinhold E. Schmidt; Roland Jacobs

doi:10.1097/QAI.0000000000001082

Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Dejene M. Tufa, Fareed Ahmad, Debanjana Chatterjee, Gerrit Ahrenstorf, Reinhold E. Schmidt, Roland Jacobs

Pediatrics - Blood/Marrow Transplant

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13 Scopus citations

Abstract

HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

Original language	English (US)
Pages (from-to)	34-38
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	73
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000001082
State	Published - Sep 1 2016

Bibliographical note

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

HIV
IL-1β
slanDCs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.",

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AB - HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

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Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

Abstract

Bibliographical note

Keywords

UN SDGs

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