TY - JOUR
T1 - Brief Report
T2 - Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV
AU - Seaman, Shanti M.
AU - Van Pilsum Rasmussen, Sarah E.
AU - Nguyen, Anh Q.
AU - Halpern, Samantha E.
AU - You, Susan
AU - Waldram, Madeleine M.
AU - Anjum, Saad K.
AU - Bowring, Mary Grace
AU - Muzaale, Abimereki D.
AU - Ostrander, Darin B.
AU - Brown, Diane
AU - Massie, Allan B.
AU - Tobian, Aaron A.R.
AU - Henderson, MacEy L.
AU - Fletcher, Faith E.
AU - Smith, Burke
AU - Chao, Ada
AU - Gorupati, Nishita
AU - Prakash, Katya
AU - Aslam, Saima
AU - Lee, Dong H.
AU - Kirchner, Varvara
AU - Pruett, Timothy L.
AU - Haidar, Ghady
AU - Hughes, Kailey
AU - Malinis, Maricar
AU - Trinh, Sonya
AU - Segev, Dorry L.
AU - Sugarman, Jeremy
AU - Durand, Christine M.
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.
AB - Background:HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access to transplantation for people living with HIV. However, it remains unknown whether transplant candidates living with HIV will accept the currently unknown risks of HIV D+/R+ transplantation.Methods:We surveyed transplant candidates living with HIV from 9 US transplant centers regarding willingness to accept HIV+ donor organs.Results:Among 116 participants, the median age was 55 years, 68% were men, and 78% were African American. Most were willing to accept HIV+ living donor organs (87%), HIV+ deceased donor organs (84%), and increased infectious risk donor organs (70%). Some (30%) were concerned about HIV superinfection; even among these respondents, 71% were willing to accept an HIV D+ organ. Respondents from centers that had already performed a transplant under an HIV D+/R+ transplantation research protocol were more willing to accept HIV+ deceased donor organs (89% vs. 71%, P = 0.04). Respondents who chose not to enroll in an HIV D+/R+ transplantation research protocol were less likely to believe that HIV D+/R+ transplantation was safe (45% vs. 77%, P = 0.02), and that HIV D+ organs would work similar to HIV D- organs (55% vs. 77%, P = 0.04), but more likely to believe they would receive an infection other than HIV from an HIV D+ organ (64% vs. 13%, P < 0.01).Conclusions:Willingness to accept HIV D+ organs among transplant candidates living with HIV does not seem to be a major barrier to HIV D+/R+ transplantation and may increase with growing HIV D+/R+ transplantation experience.
KW - HIV+ organ donation
KW - HIV+ transplantation
KW - HOPE Act
KW - transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=85088382569&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000002405
DO - 10.1097/QAI.0000000000002405
M3 - Article
C2 - 32427721
AN - SCOPUS:85088382569
SN - 1525-4135
VL - 85
SP - 88
EP - 92
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 1
ER -