Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual Cortex

Aaron M. Kerlin, Mark L. Andermann, Vladimir K. Berezovskii, R. Clay Reid

Research output: Contribution to journalArticlepeer-review

329 Scopus citations

Abstract

Different subtypes of GABAergic neurons in sensory cortex exhibit diverse morphology, histochemical markers, and patterns of connectivity. These subtypes likely play distinct roles in cortical function, but their in vivo response properties remain unclear. We used in vivo calcium imaging, combined with immunohistochemical and genetic labels, to record visual responses in excitatory neurons and up to three distinct subtypes of GABAergic neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all GABAergic subtypes had broader selectivity. Further, bias in the responses of GABAergic neurons toward particular orientations or spatial frequencies tended to reflect net biases of the surrounding neurons. These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population-a principle that may generalize across species and sensory modalities.

Original languageEnglish (US)
Pages (from-to)858-871
Number of pages14
JournalNeuron
Volume67
Issue number5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank Sergey Yurgenson for technical contributions and Soumya Chatterjee for assistance with cell-attached recordings. Aleksandr Vagodny, Demetris Roumis, Mark Henry, Lindsay Knox, Patrick Dempsey, and Derrick Brittain provided valuable technical assistance. We also thank Vincent Bonin, Kenichi Ohki, Lindsey Glickfeld, Prakash Kara, Mark Histed, Joshua Morgan, Jessica Cardin, Wei-Chung Allen Lee, Julie Haas, and Cindy Poo for advice, suggestions, and discussion. This work was supported by NIH grant R01 EY018742, grant P30 EY12196, and the Helen Hay Whitney Foundation (M.L.A.).

Fingerprint Dive into the research topics of 'Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual Cortex'. Together they form a unique fingerprint.

Cite this