Burkitt lymphoma in the modern era: Real-world outcomes and prognostication across 30 US cancer centers

Andrew M. Evens, Alexey Danilov, Deepa Jagadeesh, Amy Sperling, Seo Hyun Kim, Ryan Vaca, Catherine Wei, Daniel Rector, Suchitra Sundaram, Nishitha Reddy, Yong Lin, Umar Farooq, Christopher D'Angelo, David A. Bond, Stephanie Berg, Michael C. Churnetski, Amandeep Godara, Nadia Khan, Yun Kyong Choi, Maryam YazdyEmma Rabinovich, Gaurav Varma, Reem Karmali, Agrima Mian, Malvi Savani, Madelyn Burkart, Peter Martin, Albert Ren, Ayushi Chauhan, Catherine Diefenbach, Allandria Straker-Edwards, Andreas K. Klein, Kristie A. Blum, Kirsten Marie Boughan, Scott E. Smith, Brad M. Haverkos, Victor M. Orellana-Noia, Vaishalee P. Kenkre, Adam Zayac, Jeremy Ramdial, Seth M. Maliske, Narendranath Epperla, Parameswaran Venugopal, Tatyana A. Feldman, Stephen D. Smith, Andrzej Stadnik, Kevin A. David, Seema Naik, Izidore S. Lossos, Matthew A. Lunning, Paolo Caimi, Manali Kamdar, Neil Palmisiano, Veronika Bachanova, Craig A. Portell, Tycel Phillips, Adam J. Olszewski, Juan Pablo Alderuccio

Research output: Contribution to journalArticlepeer-review


We examined adults with untreated Burkitt lymphoma (BL) from 2009 to 2018 across 30 US cancer centers. Factors associated with progression-free survival (PFS) and overall survival (OS) were evaluated in univariate and multivariate Cox models. Among 641 BL patients, baseline features included the following: median age, 47 years; HIV1, 22%; Eastern Cooperative Oncology Group (ECOG) performance status (PS) 2 to 4, 23%; >1 extranodal site, 43%; advanced stage, 78%; and central nervous system (CNS) involvement, 19%. Treatment-related mortality was 10%, with most common causes being sepsis, gastrointestinal bleed/perforation, and respiratory failure.With 45-monthmedian follow-up, 3-year PFS andOS rates were 64% and 70%, respectively, without differences by HIV status. Survival was better for patients who received rituximab vs not (3-year PFS, 67% vs 38%; OS, 72% vs 44%; P < .001) and without difference based on setting of administration (ie, inpatient vs outpatient).Outcomeswere also improved at an academic vs community cancer center (3-year PFS, 67% vs 46%, P = .006; OS, 72% vs 53%, P = .01). In multivariate models, age 40 years (PFS, hazard ratio [HR] 5 1.70, P = .001; OS, HR 5 2.09, P < .001), ECOG PS 2 to 4 (PFS, HR 5 1.60, P < .001; OS, HR 5 1.74, P = .003), lactate dehydrogenase > 33 normal (PFS, HR 5 1.83, P < .001; OS, HR 5 1.63, P = .009), and CNS involvement (PFS, HR5 1.52, P5 .017;OS, HR5 1.67, P5 .014) predicted inferior survival. Furthermore, survival varied based on number of factors present (0, 1, 2 to 4 factors) yielding 3-year PFS rates of 91%, 73%, and 50%, respectively; and 3-year OS rates of 95%, 77%, and 56%, respectively. Collectively, outcomes for adult BL in this real-world analysis appeared more modest compared with results of clinical trials and smaller series. In addition, clinical prognostic factors at diagnosis identified patients with divergent survival rates.

Original languageEnglish (US)
Pages (from-to)374-386
Number of pages13
Issue number3
StatePublished - Jan 21 2021

Bibliographical note

Funding Information:
from Kite Pharma. N.E. is on the speaker’s bureau for Verastem Oncology and received honoraria from Pharmacyclics. N.K. has membership on an entity’s board of directors or advisory committee for Seattle Genetics and Abbvie; provides educational content/symposium for Janssen; and receives research funds from Bristol Myers. J.A. is an immediate family member who received honoraria from Puma Biotechnology, Agios, Inovio Pharmaceuticals, and Foundation Medicine; receives honoraria from Targeted Oncology; and consults for OncLive. M.Y. receives honoraria from Bayer; receives research funding from Genentech; and consults for Octapharma and Abbvie. C.D. consults for and received research funding from Bristol-Myers Squibb; receives research funding from Denovo; consults for and receives research funding from Gen-entech; receives research funding from Incyte, LAM Therapeutics, MEI, Millenium/Takeda, and Trillium; consults for and receives research funding from Merck; and consults for and receives research funding from Seattle Genetics. R.K. is on the speakers bureau for Astrazeneca; receives institutional research funding from Takeda and BMS; and consults for and is on the speakers bureau for Gilead, Kite, Juno, and Celgene. P.M. consults foe Celgene, Teneobio, Karyopharm, Janssen, Sandoz, and I-MAB. M.K. is on the speakers bureau for Seattle Genetics; consults for Pharmacyclics, AstraZeneca, and Celgene; and is employed by the University of Colorado. C.P. receives research funding from Xencor, Roche/Genentech, Infinity, TG Therapeutics, AbbVie, and Acerta/ AstraZeneca; consults for Pharmacyclics, Janssen, Amgen, and Bayer; and consults for and received research funding from Genentech, Bei-Gene, and Kite. I.L. has membership on an entity’s board of directors or advisory committee for Janssen Scientific and Seattle Genetics and receives research funding from the National Institutes of Health. A.O. receives research funding from Genentech, Adaptive Biotechnologies, TG Therapeutics, and Spectrum Pharmaceuticals. The remaining authors declare no competing financial interests.

Publisher Copyright:
© 2021 by The American Society of Hematology.

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