Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.

D. J. Simmons; C. Yang; C. M. Gundberg; L. Kidder; G. Cornelissen; M. Thomas; R. Lozano; E. Sandstead

Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.

D. J. Simmons, C. Yang, C. M. Gundberg, L. Kidder, G. Cornelissen, M. Thomas, R. Lozano, E. Sandstead

Research output: Contribution to journal › Article › peer-review

Abstract

This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.

Original language	English (US)
Pages (from-to)	517-527
Number of pages	11
Journal	Progress in clinical and biological research
Volume	341 A
State	Published - 1990

OpenUrl availability

Full text

Cite this

@article{4545359e6db542dd960b7c1fcae8290a,

title = "Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.",

abstract = "This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.",

author = "Simmons, {D. J.} and C. Yang and Gundberg, {C. M.} and L. Kidder and G. Cornelissen and M. Thomas and R. Lozano and E. Sandstead",

year = "1990",

language = "English (US)",

volume = "341 A",

pages = "517--527",

journal = "Progress in clinical and biological research",

issn = "0361-7742",

publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Calcitonin

T2 - chronotherapeutic effect on osteopenia in the ovariectomized rat.

AU - Simmons, D. J.

AU - Yang, C.

AU - Gundberg, C. M.

AU - Kidder, L.

AU - Cornelissen, G.

AU - Thomas, M.

AU - Lozano, R.

AU - Sandstead, E.

PY - 1990

Y1 - 1990

N2 - This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.

AB - This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.

UR - http://www.scopus.com/inward/record.url?scp=0025137706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025137706&partnerID=8YFLogxK

M3 - Article

C2 - 2217271

AN - SCOPUS:0025137706

SN - 0361-7742

VL - 341 A

SP - 517

EP - 527

JO - Progress in clinical and biological research

JF - Progress in clinical and biological research

ER -

Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.

Abstract

OpenUrl availability

Other files and links

Fingerprint

Cite this