Calcium and Vitamin D intake and mortality: Results from the Canadian Multicentre Osteoporosis Study (CaMos)

Lisa Langsetmo, Claudie Berger, Nancy Kreiger, Christopher S. Kovacs, David A. Hanley, Sophie A. Jamal, Susan J. Whiting, Jacques Genest, Suzanne N. Morin, Anthony Hodsman, Jerilynn C. Prior, Brian Lentle, Millan S. Patel, Jacques P. Brown, Tassos Anastasiades, Tanveer Towheed, Robert G. Josse, Alexandra Papaioannou, Jonathan D. Adachi, William D. LeslieK. Shawn Davison, David Goltzman, Alan Tenenhouse, Suzanne Godmaire, Silvia Dumont, Carol Joyce, Emma Sheppard, Susan Kirkland, Stephanie Kaiser, Barbara Stanfield, Louis Bessette, Jeanette Dumont, Barbara Matthews, Bob Josse, Tim Murray, Barbara Gardner-Bray, Laura Pickard, Wojciech P. Olszynski, Jola Thingvold, Jane Allan, Nerkeza Andjelic

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Context: Calcium and vitamin D are recommended for bone health, but there are concerns about adverse risks. Some clinical studies suggest that calcium intake may be cardioprotective, whereas others report increased risk associated with calcium supplements. Both low and high serum levels of 25-hydroxyvitamin D have been associated with increased mortality. Objective: The purpose of this study was to determine the association between total calcium and vitamin D intake and mortality and heterogeneity by source of intake. Design: The Canadian Multicentre Osteoporosis Study cohort is a population-based longitudinal cohort with a 10-year follow-up (1995-2007). Setting: This study included randomly selected community-dwelling men and women. Participants: A total of 9033 participants with nonmissing calcium and vitamin D intake data and follow-up were studied. Exposure: Total calcium intake (dairy, nondairy food, and supplements) and total vitamin D intake (milk, yogurt, and supplements) were recorded. Outcome: The outcome variable was all-cause mortality. Results: There were 1160 deaths during the 10-year period. For women only, we found a possible benefit of higher total calcium intake, with a hazard ratio of 0.95 (95% confidence interval, 0.89-1.01) per 500-mg increase in daily calcium intake and no evidence of heterogeneity by source; use of calcium supplements was also associated with reduced mortality, with hazard ratio of 0.78 (95% confidence interval, 0.66-0.92) for users vs nonusers with statistically significant reductions remaining among those with doses up to 1000 mg/d. These associations were not modified by levels of concurrent vitamin D intake. No definitive associations were found among men. Conclusions: Calcium supplements, up to 1000 mg/d, and increased dietary intake of calcium may be associated with reduced risk of mortality in women. We found no evidence of mortality benefit or harm associated with vitamin D intake.

Original languageEnglish (US)
Pages (from-to)3010-3018
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number7
DOIs
StatePublished - Jul 2013

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Copyright 2014 Elsevier B.V., All rights reserved.

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