Calmodulin levels in diabetic mice

J. E. Morley, A. S. Levine, D. M. Brown, B. S. Handwerger

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Calcium has been considered to play a role as an intracellular mediator for insulin. Many of the intracellular effects of calcium are mediated through calcium binding proteins, the most important of which is calmodulin. In this study we have demonstrated elevated levels of calmodulin as measured by radioimmunoassay in the abdominal fat, muscle, kidney and heart but not in the liver of streptozotocin-induced diabetic mice compared to their controls. Elevated calmodulin levels were also demonstrated in the kidney and heart of genetically obese, diabetic mice (C57 BL/Ks db+/db+) compared to both their heterozygote (db/m) and homozygote (m/m) controls.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume108
Issue number4
DOIs
StatePublished - Oct 29 1982

Bibliographical note

Funding Information:
were supported, in part, by grants from the American Diabetes Association

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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