Calmodulin levels in diabetic mice

J. E. Morley, A. S. Levine, D. M. Brown, B. S. Handwerger

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Calcium has been considered to play a role as an intracellular mediator for insulin. Many of the intracellular effects of calcium are mediated through calcium binding proteins, the most important of which is calmodulin. In this study we have demonstrated elevated levels of calmodulin as measured by radioimmunoassay in the abdominal fat, muscle, kidney and heart but not in the liver of streptozotocin-induced diabetic mice compared to their controls. Elevated calmodulin levels were also demonstrated in the kidney and heart of genetically obese, diabetic mice (C57 BL/Ks db+/db+) compared to both their heterozygote (db/m) and homozygote (m/m) controls.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Oct 29 1982

Bibliographical note

Funding Information:
were supported, in part, by grants from the American Diabetes Association

Copyright 2018 Elsevier B.V., All rights reserved.


Dive into the research topics of 'Calmodulin levels in diabetic mice'. Together they form a unique fingerprint.

Cite this