Abstract
A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.
Original language | English (US) |
---|---|
Pages (from-to) | 1739-1746 |
Number of pages | 8 |
Journal | Biology of Blood and Marrow Transplantation |
Volume | 17 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2011 |
Externally published | Yes |
Keywords
- G-CSF
- Peripheral blood progenitor cell mobilization
- Stem cell donors