Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Matthew Glen Robertson; Benjamin Bruce Eidenschink; Eriko Iguchi; Stanislav O. Zakharkin; Christopher J. LaRocca; Ezequiel J. Tolosa; Mark J. Truty; Kari Jacobsen; Martin E. Fernandez-Zapico; Julia Davydova

doi:10.1016/j.omto.2021.03.002

Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Matthew Glen Robertson, Benjamin Bruce Eidenschink, Eriko Iguchi, Stanislav O. Zakharkin, Christopher J. LaRocca, Ezequiel J. Tolosa, Mark J. Truty, Kari Jacobsen, Martin E. Fernandez-Zapico, Julia Davydova

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Abstract

Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

Original language	English (US)
Pages (from-to)	659-668
Number of pages	10
Journal	Molecular Therapy - Oncolytics
Volume	20
DOIs	https://doi.org/10.1016/j.omto.2021.03.002
State	Published - Mar 26 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

Adenovirus
Adenovirus Death Protein
Cancer imaging
Oncolytic Virus
Pancreatic cancer
Radiotherapy
Sodium-iodide symporter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Robertson, M. G., Eidenschink, B. B., Iguchi, E., Zakharkin, S. O., LaRocca, C. J., Tolosa, E. J., Truty, M. J., Jacobsen, K., Fernandez-Zapico, M. E., & Davydova, J. (2021). Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion. Molecular Therapy - Oncolytics, 20, 659-668. https://doi.org/10.1016/j.omto.2021.03.002

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abstract = "Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.",

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doi = "10.1016/j.omto.2021.03.002",

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AU - Eidenschink, Benjamin Bruce

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AU - Zakharkin, Stanislav O.

AU - LaRocca, Christopher J.

AU - Tolosa, Ezequiel J.

AU - Truty, Mark J.

AU - Jacobsen, Kari

AU - Fernandez-Zapico, Martin E.

AU - Davydova, Julia

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AB - Sodium iodide symporter (NIS)-expressing oncolytic viruses enable tumor-specific imaging and radiotherapy for infected tumors. We designed a novel NIS-expressing adenoviral vector with deletion of the adenovirus death protein (ADP) gene. ADP deletion improved NIS expression and subsequent imaging capabilities highlighting the role of vector design in effective transgene expression.

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KW - Oncolytic Virus

KW - Pancreatic cancer

KW - Radiotherapy

KW - Sodium-iodide symporter

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Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Abstract

Bibliographical note

Keywords

UN SDGs

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