Canine urate urolithiasis: Etiopathogenesis, diagnosis, and management

J. W. Bartges, C. A. Osborne, J. P. Lulich, J. M. Kruger, S. L. Sanderson, L. A. Koehler, L. K. Ulrich

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Etiopathologic factors predisposing to urate lithogenesis in Dalmatian and non-Dalmatian dogs represent diverse pathologic and/or physiologic processes involving purine nucleotide and ammonia synthesis, biodegradation, and excretion. Predisposing factors for urate urolith formation include hyperuricemia, hyperammonemia, hyperuricosuria, hyperammonuria, aciduria, and genetic predisposition. Medical therapy of dogs forming urate uroliths should be directed at modifying these predisposing factors through dietary modification, administration of allopurinol, and/or surgical correction of portovascular anomalies if present. The precise mechanisms resulting in urate urolith formation in dogs have not been determined.

Original languageEnglish (US)
Pages (from-to)161-191
Number of pages31
JournalVeterinary Clinics of North America - Small Animal Practice
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1999

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