TY - JOUR
T1 - Carbocyclic arabinofuranosyladenine (cyclaradine)
T2 - Efficacy against genital herpes in guinea pigs
AU - Vince, Robert
AU - Daluge, Susan
AU - Lee, Heejoo
AU - Shannon, William M.
AU - Arnett, Gussie
AU - Schafer, Thomas W.
AU - Nagabhushan, Tattanahalli L.
AU - Reichert, Paul
AU - Tsai, Hsingan
PY - 1983
Y1 - 1983
N2 - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
AB - Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5′-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
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U2 - 10.1126/science.6684328
DO - 10.1126/science.6684328
M3 - Article
C2 - 6684328
AN - SCOPUS:0020525820
SN - 0036-8075
VL - 221
SP - 1405
EP - 1406
JO - Science
JF - Science
IS - 4618
ER -