Carbon-13 and Nitrogen-15 Spin-Lattice Relaxation (T1) and Nuclear Overhauser Enhancement (NOE) Measurements for Acetamide and N,N-Dimethylacetamide

Donald D. Giannini, Ian M. Armitage, Harry Pearson, David M. Grant, John D. Roberts

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Nitrogen-15 spin-lattice relaxation times (T1's) and nuclear Overhauser enhancement (NOE) values are found to vary over a range of concentrations for acetamide. Our data indicate that intermolecular amide-amide hydrogen bonds are broken on dilution in water. Carbon-13 spin-lattice relaxation times and nuclear Overhauser enhancement measurements are given for acetamide and N,N-dimethylacetamide at 5.3 M. There is good agreement between experimental and calculated relaxation rates assuming rapid rotation of the α-methyl group and slow rotation about the amide bond.

Original languageEnglish (US)
Pages (from-to)3416-3419
Number of pages4
JournalJournal of the American Chemical Society
Volume97
Issue number12
DOIs
StatePublished - Jun 1 1975
Externally publishedYes

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