A new study demonstrates that lifetime whole-body exposure of B6C3F1 mice to high doses of cigarette smoke robustly increases lung cancer incidence compared with sham exposed animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on lung cancer in an animal model. This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations and possible applications of available models.
Bibliographical noteFunding Information:
Research on tobacco and cancer in the author laboratory is supported by grants CA-81301 and DA-13333 from the NIH and RP-00-138 from the American Cancer Society.