Cardiac remodeling as a consequence of atrial fibrillation: An anatomical study of perfusion-fixed human heart specimens

Christopher D. Rolfes, Stephen A. Howard, Ryan P. Goff, Paul A. Iaizzo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Atrial fibrillation (AF) causes a continuum of atrial anatomical remodeling. Methods: Using a library of perfusion-fixed human hearts, specimens with AF were compared to controls. During this preliminary assessment study, direct measurements were taken of atrial volume, pulmonary vein (PV) circumference, and left atrial (LA) wall thicknesses. Results: Hearts with AF typically had larger atrial volumes, as well as a much larger variation in volume compared to controls (range of 59.6-227.1 mL in AF hearts compared to 65.1-115.9 mL in controls). For all hearts, right PVs were larger than left PVs (mean: 171.4 ± 84.6 mm2 for right and 118.2 ± 50.1 mm2for left, P < 0.005). LA wall thicknesses ranged from 0.7 mm to 3.1 mm for both AF and control hearts. Conclusions: Hearts with AF had a large range of sizes which is consistent with the progression of atrial remodeling during AF. The large range of thicknesses will influence the amount of energy needed to create transmural lesions during ablation procedures.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalJournal of Geriatric Cardiology
Volume8
Issue number3
DOIs
StatePublished - Oct 11 2011

Keywords

  • Atrial fibrillation
  • Left atrial dimensions
  • Pulmonary vein ostia
  • Volumes

Fingerprint

Dive into the research topics of 'Cardiac remodeling as a consequence of atrial fibrillation: An anatomical study of perfusion-fixed human heart specimens'. Together they form a unique fingerprint.

Cite this