Cardiac transplantation: Immunobiology and immunotherapy

Ziad Taimeh, Daniel J. Garry

Research output: Chapter in Book/Report/Conference proceedingChapter


The first successful heart transplant in 1967 brought hope for those with end-stage heart disease. Unfortunately, survival posttransplant was limited in the early years, mainly due to acute rejection and complications from immunosuppressive therapy. Over the decades, advances in tissue typing and donor-recipient matching, as well as in immunotherapy gradually increased the numbers of patients receiving heart transplants and their survival rates. This chapter details the immune system and its critical role in transplant success. It also describes how various immunosuppressive agents can overcome challenges posed by the immune system and lead to enhanced acceptance/tolerance of the donor heart.

Original languageEnglish (US)
Title of host publicationCongestive Heart Failure and Cardiac Transplantation
Subtitle of host publicationClinical, Pathology, Imaging and Molecular Profiles
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783319445779
ISBN (Print)9783319445755
StatePublished - Jun 1 2017


  • Adaptive immunity
  • Cardiac transplantation
  • Complement cascade
  • Cyclosporine
  • Immunosuppressive agents
  • Immunosuppressive therapy
  • Transplant immunobiology


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