Cardiac troponin assays: A review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction

Beret E. Amundson, Fred S. Apple

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Cardiac troponin (cTn) I and T are released from myocardial cells following necrosis, i.e., cell death. An accurate measure of cTn concentrations in a patient's blood following ischemia/chest pain can enable providers to determine whether or not a myocardial infarction (MI) has occurred. Point-of-care (POC) devices that measure blood cTn concentrations in under 30 min may help to significantly reduce hospital costs by managing and triaging patients out of the emergency department as quickly as possible. The use of POC devices that measure cTnI and cTnT with a coefficient of variation (CV) ≤20% at the 99th percentile upper reference limit (URL) limits both false positive and negative results and provides clinically acceptable findings to assist in appropriate diagnoses. This article reviews nine POC devices that measure cTn in terms of their clinical sensitivity and specificity, analytical imprecision, sample type and preparation, and each assay's principle of analysis.

Original languageEnglish (US)
Pages (from-to)665-676
Number of pages12
JournalClinical Chemistry and Laboratory Medicine
Issue number5
StatePublished - Apr 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Financial support: Professor Apple s research laboratory at the Minneapolis Medical Research Foundation of Hennepion County Medical Center has received research funding from the large majority of biomarker companies that manufacture and market cTnI and cTnT assays. Employment or leadership: None declared. Honorarium: None declared. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Publisher Copyright:
© 2015 by De Gruyter.


  • cardiac troponin
  • immunoassay
  • point-of-care

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