TY - JOUR
T1 - Cardiorenal syndrome type 1
T2 - Renal dysfunction in acute decompensated heart failure
AU - Prins, Kurt W.
AU - Thenappan, Thenappan
AU - Markowitz, Jeremy S.
AU - Pritzker, Marc R.
N1 - Publisher Copyright:
Copyright 2015 by Turner White Communications Inc., Wayne, PA. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Objective: To present a review of cardiorenal syndrome type 1 (CRS1). Methods: Review of the literature. Results: Acute kidney injury occurs in approximately one-third of patients with acute decompensated heart failure (ADHF) and the resultant condition was named CRS1. A growing body of literature shows CRS1 patients are at high risk for poor outcomes, and thus there is an urgent need to understand the pathophysiology and subsequently develop effective treatments. In this review we discuss prevalence, proposed pathophysiology including hemodynamic and nonhemodynamic factors, prognosticating variables, data for different treatment strategies, and ongoing clinical trials and highlight questions and problems physicians will face moving forward with this common and challenging condition. Conclusion: Further research is needed to understand the pathophysiology of this complex clinical entity and to develop effective treatments.
AB - Objective: To present a review of cardiorenal syndrome type 1 (CRS1). Methods: Review of the literature. Results: Acute kidney injury occurs in approximately one-third of patients with acute decompensated heart failure (ADHF) and the resultant condition was named CRS1. A growing body of literature shows CRS1 patients are at high risk for poor outcomes, and thus there is an urgent need to understand the pathophysiology and subsequently develop effective treatments. In this review we discuss prevalence, proposed pathophysiology including hemodynamic and nonhemodynamic factors, prognosticating variables, data for different treatment strategies, and ongoing clinical trials and highlight questions and problems physicians will face moving forward with this common and challenging condition. Conclusion: Further research is needed to understand the pathophysiology of this complex clinical entity and to develop effective treatments.
UR - http://www.scopus.com/inward/record.url?scp=84944268772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944268772&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:84944268772
SN - 1079-6533
VL - 22
SP - 443
EP - 454
JO - Journal of Clinical Outcomes Management
JF - Journal of Clinical Outcomes Management
IS - 10
ER -