Cardiovascular Effects of Transcranial Direct Current Stimulation and Bimanual Training in Children with Cerebral Palsy

Manda L. Keller-Ross, Daniel P. Chantigian, Samuel Nemanich, Bernadette T. Gillick

Research output: Contribution to journalArticlepeer-review


Purpose: To determine the influence of combined transcranial direct current stimulation (tDCS) to the motor cortex (M1) and bimanual training on cardiovascular function in children with cerebral palsy (CP). Methods: Mean arterial pressure (MAP), heart rate (HR), and HR variability (HRV) were measured immediately before and after 20 minutes of cathodal tDCS to contralesional M1 and bimanual training on days 1, 6, and 10 of a 10-day trial in 8 participants (5 females, 7-19 years). Results: Baseline MAP and HR were similar across days (93 ± 10 mm Hg and 90 ± 10 bpm, P >.05). MAP was similar from baseline to postintervention across all 3 days. Systolic pressure, diastolic pressure, nor HR significantly changed. HRV was not influenced by the 10-day intervention. Conclusions: Combined cathodal tDCS to M1 and bimanual training does not influence autonomic and cardiovascular function in children with CP due to perinatal stroke.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalPediatric Physical Therapy
Issue number1
StatePublished - Jan 2021

Bibliographical note

Funding Information:
Grant Support: This study was funded by the National Institutes of Health (NIH) Eunice Kennedy Shriver National Institute of Child Health and Development K01 Award (HD078484-01A1), the Cerebral Palsy Foundation, the Foundation for Physical Therapy Magistro Family Grant, Minnesota’s Discovery, Research and InnoVation Economy (MnDRIVE), and the University of Minnesota Marie Louise Wales Fellowship. The project described was also supported in part by Award UL1 TR000114 and KL2 TR000113.

Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.


  • autonomic dysfunction
  • blood pressure
  • cortical stimulation
  • heart rate
  • noninvasive brain stimulation
  • stroke

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Cardiovascular Effects of Transcranial Direct Current Stimulation and Bimanual Training in Children with Cerebral Palsy'. Together they form a unique fingerprint.

Cite this