Cardiovascular manifestations of moderate to severe carbon monoxide poisoning

Daniel Satran, Christopher R. Henry, Cheryl Adkinson, Caren I. Nicholson, Yiscah Bracha, Timothy D. Henry

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

OBJECTIVES: We describe the cardiovascular manifestations of carbon monoxide (CO) poisoning. BACKGROUND: Carbon monoxide poisoning is a common cause of toxicologic morbidity and mortality. Although the neurologic sequelae of CO poisoning have been well described, the cardiovascular consequences are limited to isolated case reports. METHODS: We reviewed the cardiovascular manifestations of 230 consecutive patients treated for moderate to severe CO poisoning in the hyperbaric oxygen chamber at Hennepin County Medical Center (HCMC), a regional center for treatment of CO poisoning. RESULTS: The mean age was 47.2 years with 72% men. Ischemic electrocardiogram (ECG) changes were present in 30% of patients, whereas only 16% had a normal ECG. Cardiac biomarkers (creatine kinase-MB fraction or troponin I) were elevated in 35% of patients. In-hospital mortality was 5%. CONCLUSIONS: Cardiovascular sequelae of CO poisoning are frequent, with myocardial injury assessed by biomarkers or ECG in 37% of patients. Patients admitted to the hospital with CO poisoning should have a baseline ECG and serial cardiac biomarkers.

Original languageEnglish (US)
Pages (from-to)1513-1516
Number of pages4
JournalJournal of the American College of Cardiology
Volume45
Issue number9
DOIs
StatePublished - May 3 2005

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