TY - JOUR
T1 - Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord
AU - Garry, Mary G.
AU - Richardson, Jennelle Durnett
AU - Hargreaves, Kenneth M.
PY - 1994/5/16
Y1 - 1994/5/16
N2 - Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.
AB - Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord.
KW - Carrageenan Inflammation
KW - Dorsal horn
KW - Hyperalgesia
KW - Immunoreactive cAMP
KW - Immunoreactive cGMP
UR - http://www.scopus.com/inward/record.url?scp=0028255858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028255858&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(94)90066-3
DO - 10.1016/0006-8993(94)90066-3
M3 - Article
C2 - 8055330
AN - SCOPUS:0028255858
SN - 0006-8993
VL - 646
SP - 135
EP - 139
JO - Brain Research
JF - Brain Research
IS - 1
ER -