Cartilage evaluation with biochemical MR imaging using in vivo Knee compression at 3T-comparison of patients after cartilage repair with healthy volunteers

Elisabeth Schoenbauer, Pavol Szomolanyi, Toshiyuki Shiomi, Vladimir Juras, Štefan Zbýň, Lukas Zak, Michael Weber, Siegfried Trattnig

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Magnetic resonance (MR) transverse relaxation time (T2) mapping has been frequently used to evaluate collagen content and its organization. In this study, MR T2 mapping, using the multi-slice, multi-echo Carr-Purcell-Meiboom-Gill technique, was performed in volunteers and patients after matrix-associated autologous chondrocyte transplantation (MACT) under unloading and loading conditions with an MR-compatible compression device. In the volunteer study, a statistically significant decrease in the cartilage MR T2 values was observed during the loading phase when compared to the initial load-free measurement. During the recovery period, a statistically significant increase in the T2 values was found in the central superficial layer (p=0.001), the central deep layer (p=0.005), the posterior deep layer (p=0.001), and in the tibia superficial layer (p=0.01) when compared to measurements under loading. In patients after MACT, during unloading or loading conditions, statistically significant changes in T2 values were observed in the transplant deep zone (p=0.005), in the posterior deep zone (p=0.004), and in the tibia superficial zone (p=0.012). The results of this study show that MR T2 mapping under loading conditions may provide additional information about cartilage repair tissue composition and organization during the postoperative follow-up, and may help to evaluate the efficacy of cartilage-repair surgery techniques.

Original languageEnglish (US)
Article number7265
Pages (from-to)3349-3355
Number of pages7
JournalJournal of Biomechanics
Volume48
Issue number12
DOIs
StatePublished - Sep 18 2015
Externally publishedYes

Bibliographical note

Funding Information:
Funding support provided by the Austrian Science Fund (FWF) P 25246 B24 , Vienna Advanced Imaging Center (VIACLIC) des Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF) FA102A0017 , and the Slovak Scientific Grant Agency VEGA ( VEGA2/0013/14 ).

Publisher Copyright:
© 2015 Elsevier Ltd.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

Keywords

  • 3T T Mapping
  • Articular cartilage
  • Autologous chondrocyte transplantation
  • In vivo cartilage loading
  • MRI

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