Catalytic carbon-carbon σ bond activation: An intramolecular carbo-acylation reaction with acylquinolines

Ashley M. Dreis, Christopher J Douglas

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

Carbon-carbon sigma-bond activation is a contemporary challenge for organometallic chemistry and catalysis. Herein, we disclose a new alkene carboacylation reaction initiated by quinoline-directed, rhodium-catalyzed C-C bond activation. The alkene carboacylation allows for the construction of all-carbon quaternary centers, with a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)412-413
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number2
DOIs
StatePublished - Jan 21 2009

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