Catecholamine effects on dissociated tiger salamander Muller (glial) cells

Diane S. Henshel; Robert F. Miller

doi:10.1016/0006-8993(92)90081-J

Catecholamine effects on dissociated tiger salamander Muller (glial) cells

Diane S. Henshel, Robert F. Miller

Neuroscience

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Abstract

Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (R_n). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in R_n. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 μM, indicating that 100 μM CA maximally stimulated the Muller cell response.

Original language	English (US)
Pages (from-to)	208-214
Number of pages	7
Journal	Brain Research
Volume	575
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)90081-J
State	Published - Mar 20 1992

Keywords

Catecholamine
Dopamine
Epinephrine
Glia
Muller cell
Retina
Salamander
Whole-cell recording

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abstract = "Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in Rn. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 μM, indicating that 100 μM CA maximally stimulated the Muller cell response.",

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AU - Miller, Robert F.

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N2 - Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in Rn. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 μM, indicating that 100 μM CA maximally stimulated the Muller cell response.

AB - Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in Rn. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 μM, indicating that 100 μM CA maximally stimulated the Muller cell response.

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KW - Dopamine

KW - Epinephrine

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KW - Salamander

KW - Whole-cell recording

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Catecholamine effects on dissociated tiger salamander Muller (glial) cells

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