Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: A magnetic resonance imaging study

George J. Jurjus, Stephen C. Olson, Steven B. Schwarzkopf

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61 Scopus citations

Abstract

Many structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18.9 %, and of all psychotic subjects 18.1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9.7%, P = 0.01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0.02). No clinical difference was found between schizophrenics with or without CSP.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalPsychological medicine
Volume23
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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