TY - JOUR
T1 - Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls
T2 - A magnetic resonance imaging study
AU - Jurjus, George J.
AU - Olson, Stephen C.
AU - Schwarzkopf, Steven B.
PY - 1993
Y1 - 1993
N2 - Many structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18.9 %, and of all psychotic subjects 18.1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9.7%, P = 0.01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0.02). No clinical difference was found between schizophrenics with or without CSP.
AB - Many structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18.9 %, and of all psychotic subjects 18.1 % had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9.7%, P = 0.01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0.02). No clinical difference was found between schizophrenics with or without CSP.
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U2 - 10.1017/S0033291700028403
DO - 10.1017/S0033291700028403
M3 - Article
C2 - 8332648
AN - SCOPUS:0027213801
SN - 0033-2917
VL - 23
SP - 319
EP - 322
JO - Psychological medicine
JF - Psychological medicine
IS - 2
ER -