CD25+Foxp3+ regulatory T cells facilitate CD4 + T cell clonal anergy induction during the recovery from lymphopenia

Tracy L. Vanasek, Sarada L. Nandiwada, Marc Jenkins, Daniel L Mueller

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective. Exposure to a tolerizing peptide Ag regimen instead induced aggressive CD4+ cell cycle progression and increased Ag responsiveness (priming). Reconstitution of T cell-deficient mice by an adoptive transfer of mature peripheral lymphocytes was accompanied by the development of a CD25+Foxp3+CTLA-4+CB4+ regulatory T cell population that acted to dampen Ag-driven cell cycle progression and facilitate the induction of clonal anergy in nearby responder CB25 -CB4+ T cells. Thus, an early recovery of CD25+ regulatory T cells following a lympliopenic event can prevent exuberant Ag-stimulated CD4+ cell cycle progression and promote the development of clonal anergy.

Original languageEnglish (US)
Pages (from-to)5880-5889
Number of pages10
JournalJournal of Immunology
Volume176
Issue number10
DOIs
StatePublished - May 15 2006

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