CD38/cyclic ADP-ribose signaling: Role in the regulation of calcium homeostasis in airway smooth muscle

Deepak A. Deshpande, Thomas A. White, Soner Dogan, Timothy F. Walseth, Reynold A. Panettieri, Mathur S. Kannan

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations

Abstract

The contractility of airway smooth muscle cells is dependent on dynamic changes in the concentration of intracellular calcium. Signaling molecules such as inositol 1,4,5-trisphosphate and cyclic ADP-ribose play pivotal roles in the control of intracellular calcium concentration. Alterations in the processes involved in the regulation of intracellular calcium concentration contribute to the pathogenesis of airway diseases such as asthma. Recent studies have identified cyclic ADP-ribose as a calcium-mobilizing second messenger in airway smooth muscle cells, and modulation of the pathway involved in its metabolism results in altered calcium homeostasis and may contribute to airway hyperresponsiveness. In this review, we describe the basic mechanisms underlying the dynamics of calcium regulation and the role of CD38/cADPR, a novel pathway, in the context of airway smooth muscle function and its contribution to airway diseases such as asthma.

Original languageEnglish (US)
Pages (from-to)L773-L788
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume288
Issue number5 32-5
DOIs
StatePublished - May 2005

Keywords

  • 12.6-kDa FK506-binding protein
  • Calcium oscillations
  • Inflammatory cytokines
  • Muscarinic receptors
  • Ryanodine receptor

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