CD4+; T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation

Ryan W. Nelson, James B. McLachlan, Jonathan R. Kurtz, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

CD4+; memory-phenotype T cells decline over time when generated in response to acute infections cleared by other components of the immune system. Therefore, it was of interest to assess the stability of CD4 +; T cells during a persistent Salmonella infection, which is typical of persistent phagocytic infections that are controlled by this lymphocyte subset. We found that CD4+; T cells specific for Salmonella peptide:MHC class II (MHCII) ligands were numerically stable for >1 y after initial oral infection. This stability was associated with peptide:MHCII-driven proliferation by a small number of T cells in the secondary lymphoid organs that harbored bacteria. The persistent population consisted of multifunctional Th1 cells that induced PD-1 and became exhausted when transferred to hosts expressing the specific peptide:MHCII ligand in all parts of the body. Thus, persistent infection of phagocytes produced a CD4+; T cell population that was stably maintained by low-level peptide:MHCII presentation.

Original languageEnglish (US)
Pages (from-to)2828-2834
Number of pages7
JournalJournal of Immunology
Volume190
Issue number6
DOIs
StatePublished - Mar 15 2013

Fingerprint Dive into the research topics of 'CD4<sup>+</sup>; T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation'. Together they form a unique fingerprint.

Cite this