CD4+ T cells coexpressing CD134 (OX40) harbor significantly increased levels of human herpesvirus 6b DNA following umbilical cord blood transplantation

Joshua C. Pritchett, Jaime S. Green, Angela M. Thomm, Konstance K. Knox, Michael R. Verneris, Troy C. Lund

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.

Original languageEnglish (US)
Pages (from-to)1911-1915
Number of pages5
JournalJournal of Infectious Diseases
Volume214
Issue number12
DOIs
StatePublished - Dec 1 2016

Bibliographical note

Funding Information:
Financial support. This work was supported by the American Society of Hematology (Hematology Opportunities for the Next Generation of Research Scientists grant to J. C. P.) and the National Institutes of Health (grants RO1AI100879 [to M. R. V.] and PO1CA065493 [to M. R. V.]).

Publisher Copyright:
© The Author 2016.

Keywords

  • CD134
  • HHV-6
  • Herpesvirus
  • OX40
  • Umbilical cord blood transplantation

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