TY - JOUR
T1 - CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine
AU - Curtsinger, Julie M.
AU - Johnson, Christopher M.
AU - Mescher, Matthew F.
PY - 2003/11/15
Y1 - 2003/11/15
N2 - Full activation of naive CD8 T cells requires Ag, costimulation, and a third signal that can be provided by IL-12. Brief exposure (6 h) to Ag and B7-1 is sufficient to stimulate multiple rounds of cell division, but clonal expansion and development of effector function are minimal even when signal 3 is present. Full activation instead requires concerted signaling by Ag, B7-1, and IL-12 for greater than 40 h. Thus, the gene expression program required for cell division can be initiated by brief interaction with Ag and costimulation, but maintaining the expression of the genes needed for survival and effector function requires prolonged signaling by a signal 3 cytokine in concert with Ag and costimulation.
AB - Full activation of naive CD8 T cells requires Ag, costimulation, and a third signal that can be provided by IL-12. Brief exposure (6 h) to Ag and B7-1 is sufficient to stimulate multiple rounds of cell division, but clonal expansion and development of effector function are minimal even when signal 3 is present. Full activation instead requires concerted signaling by Ag, B7-1, and IL-12 for greater than 40 h. Thus, the gene expression program required for cell division can be initiated by brief interaction with Ag and costimulation, but maintaining the expression of the genes needed for survival and effector function requires prolonged signaling by a signal 3 cytokine in concert with Ag and costimulation.
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U2 - 10.4049/jimmunol.171.10.5165
DO - 10.4049/jimmunol.171.10.5165
M3 - Article
C2 - 14607916
AN - SCOPUS:0242579946
SN - 0022-1767
VL - 171
SP - 5165
EP - 5171
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -