Cdc20 in S-phase: The banquo at replication's banquet

Catherine A. Andrews; Marisa Segal; Steven I. Reed; Duncan J. Clarke

Cdc20 in S-phase: The banquo at replication's banquet

Catherine A. Andrews, Marisa Segal, Steven I. Reed, Duncan J. Clarke

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize, interact with, and ubiquitylate key proteins that block cell cycle progression. The specificity factors, Cdc20p and Cdh1p, are not always associated with the APC/C and indeed they have the ability to interact with substrates in isolation. The molecular events that take place in order for Cdc20p and Cdh1p to couple substrates and APC/C are currently being resolved. Meanwhile, evidence has emerged suggesting that at least one of the specificity factors, Cdc20p, might be capable of functioning independently of the APC/C.

Original language	English (US)
Pages (from-to)	274-277
Number of pages	4
Journal	Cell Cycle
Volume	3
Issue number	3
State	Published - Mar 2004

Keywords

APC
Cdc20
Checkpoint
Mec1
Pds1
Rad53
S-phase
Securin

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Full text

Cite this

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title = "Cdc20 in S-phase: The banquo at replication's banquet",

abstract = "The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize, interact with, and ubiquitylate key proteins that block cell cycle progression. The specificity factors, Cdc20p and Cdh1p, are not always associated with the APC/C and indeed they have the ability to interact with substrates in isolation. The molecular events that take place in order for Cdc20p and Cdh1p to couple substrates and APC/C are currently being resolved. Meanwhile, evidence has emerged suggesting that at least one of the specificity factors, Cdc20p, might be capable of functioning independently of the APC/C.",

keywords = "APC, Cdc20, Checkpoint, Mec1, Pds1, Rad53, S-phase, Securin",

author = "Andrews, {Catherine A.} and Marisa Segal and Reed, {Steven I.} and Clarke, {Duncan J.}",

year = "2004",

month = mar,

language = "English (US)",

volume = "3",

pages = "274--277",

journal = "Cell Cycle",

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TY - JOUR

T1 - Cdc20 in S-phase

T2 - The banquo at replication's banquet

AU - Andrews, Catherine A.

AU - Segal, Marisa

AU - Reed, Steven I.

AU - Clarke, Duncan J.

PY - 2004/3

Y1 - 2004/3

N2 - The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize, interact with, and ubiquitylate key proteins that block cell cycle progression. The specificity factors, Cdc20p and Cdh1p, are not always associated with the APC/C and indeed they have the ability to interact with substrates in isolation. The molecular events that take place in order for Cdc20p and Cdh1p to couple substrates and APC/C are currently being resolved. Meanwhile, evidence has emerged suggesting that at least one of the specificity factors, Cdc20p, might be capable of functioning independently of the APC/C.

AB - The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize, interact with, and ubiquitylate key proteins that block cell cycle progression. The specificity factors, Cdc20p and Cdh1p, are not always associated with the APC/C and indeed they have the ability to interact with substrates in isolation. The molecular events that take place in order for Cdc20p and Cdh1p to couple substrates and APC/C are currently being resolved. Meanwhile, evidence has emerged suggesting that at least one of the specificity factors, Cdc20p, might be capable of functioning independently of the APC/C.

KW - APC

KW - Cdc20

KW - Checkpoint

KW - Mec1

KW - Pds1

KW - Rad53

KW - S-phase

KW - Securin

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M3 - Short survey

C2 - 14726678

AN - SCOPUS:16544384751

SN - 1538-4101

VL - 3

SP - 274

EP - 277

JO - Cell Cycle

JF - Cell Cycle

IS - 3

ER -

Cdc20 in S-phase: The banquo at replication's banquet

Abstract

Keywords

OpenUrl availability

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