TY - JOUR
T1 - Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity
AU - Leonard, B. A.B.
AU - Lee, P. K.
AU - Jenkins, M. K.
AU - Schlievert, P. M.
PY - 1991
Y1 - 1991
N2 - Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken. SPEs A, B, and C were mitogenic for C57BL10/SnJ and BALB/cWAT T cells, with activities differing in intensity depending on the mouse strain and toxin employed. SPE-induced, T-cell-proliferative activity was dependent on class II major histocompatibility complex molecules expressed on antigen-presnting cells. The abilities of SPEs A, B, and C to preferentially stimulate murine cells with certain T-cell receptor Vβs were investigated by fluorescence-activated cell sorter analysis. SPE A preferentially activated T cells expressing Vβ 8 but Vβ 3, 6, or 11, while SPEs B and C preferentially stimulated T cells which did not express any of the tested Vβs.
AB - Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken. SPEs A, B, and C were mitogenic for C57BL10/SnJ and BALB/cWAT T cells, with activities differing in intensity depending on the mouse strain and toxin employed. SPE-induced, T-cell-proliferative activity was dependent on class II major histocompatibility complex molecules expressed on antigen-presnting cells. The abilities of SPEs A, B, and C to preferentially stimulate murine cells with certain T-cell receptor Vβs were investigated by fluorescence-activated cell sorter analysis. SPE A preferentially activated T cells expressing Vβ 8 but Vβ 3, 6, or 11, while SPEs B and C preferentially stimulated T cells which did not express any of the tested Vβs.
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M3 - Article
C2 - 1997426
AN - SCOPUS:0026012887
SN - 0019-9567
VL - 59
SP - 1210
EP - 1214
JO - Infection and immunity
JF - Infection and immunity
IS - 3
ER -