Cell cycle regulators and lineage-specific therapeutic targets for cushing disease

Takako Araki; Ning Ai Liu

doi:10.3389/fendo.2018.00444

Cell cycle regulators and lineage-specific therapeutic targets for cushing disease

Takako Araki, Ning Ai Liu

Medicine - Endocrine and Diabetes Division

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

Original language	English (US)
Article number	444
Journal	Frontiers in Endocrinology
Volume	9
Issue number	AUG
DOIs	https://doi.org/10.3389/fendo.2018.00444
State	Published - Aug 10 2018

Bibliographical note

Funding Information:
The authors thank Shira Berman for technical advice and assistance. This work was supported by NIH grants R21DK103198 (N-AL) and T32DK007770 (TA). The funding sources had no role in study design, data analysis, or decision to publish.

Publisher Copyright:
© 2018 Araki and Liu.

Keywords

Cell cycle
Cushing disease
Cyclin E
E2F1
POMC
Pituitary tumor

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abstract = "Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.",

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Cell cycle regulators and lineage-specific therapeutic targets for cushing disease

Abstract

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Keywords

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