Cell transplantation for ischemic heart disease

Mohammad N. Jameel, Joseph Lee, Daniel J. Garry, Jianyi Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiomyocyte regeneration may occur during physiological and pathological states in the adult heart; these data highlight the possibility that myocardial regeneration may occur via cardiomyocyte proliferation and/or differentiation of putative cardiac stem cells. To date, various cell types have been used for cardiac repair, including skeletal myoblasts, bone marrow-derived cells, mesenchymal stem cells, endothelial progenitor cells, umbilical cord blood stem cells, cardiac stem cells, and embryonic stem cells. This chapter will review each of these different stem cell populations in regard to the potential treatment of heart disease. It begins by examining the in vitro and in vivo animal studies, and then briefly discusses the cell therapy clinical trials that are currently underway for treating ischemic heart disease.

Original languageEnglish (US)
Title of host publicationHandbook of Cardiac Anatomy, Physiology, and Devices
Subtitle of host publicationSecond Edition
PublisherHumana Press
Pages613-629
Number of pages17
ISBN (Print)9781588294432
DOIs
StatePublished - Dec 1 2005

Keywords

  • Adult stem cells
  • Bone marrow-derived stem cells
  • Cardiac stem cells
  • Embryonic stem cells
  • Endothelial progenitor cells
  • Mesenchymal stem cells
  • Skeletal myoblasts
  • Umbilical cord blood stem cells

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