Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. SchmittJohn Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations

Abstract

The cellular state of “senescence” has proven difficult to define, presenting an obstacle for progress in the field. This perspective provides a consensus on the cellular and molecular features of senescence from 26 field leaders.

Original languageEnglish (US)
Pages (from-to)813-827
Number of pages15
JournalCell
Volume179
Issue number4
DOIs
StatePublished - Oct 31 2019

Bibliographical note

Funding Information:
We would like to thank Nikolaos Kastrinakis, Panagiotis V.S. Vasileiou, Gkikas Magiorkinis, Eleni Fitsiou, and Michela Borghesan for their valuable support to this work. We apologize in advance that, for reason of space, we have omitted the citations of relevant papers and reviews. M.D. is funded by the Dutch Cancer Foundation, Netherlands (grant ID 10989). V.G. K.E. and K.V. were financially supported by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grants agreement no. 722729 (SYNTRAIN); the Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece; the KIKPE Foundation, Athens, Greece; Pentagon Biotechnology, UK; DeepMed IO, UK; grant no. 775 from the Hellenic Foundation for Research and Innovation (HFRI); and NKUA-SARG grants 70/3/9816, 70/3/12128, and 70/3/15603. M.S.: is funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) (SAF2013-48256-R), the European Research Council (ERC-2014-AdG/669622), and ?laCaixa? Foundation. M.D. is a cofounder and shareholder of Cleara Biotech and holds patents related to senolytics. A.A. is a cofounder and shareholder of Oncosence. J.C. is a cofounder and shareholder of Unity Biotechnology and holds patents related to senolytics. D.Z. is a cofounder and shareholder of Unity Biotechnology and holds patents related to senolytics. J.G. owns equity in and has acted as a consultant for Unity Biotechnology; is a scientific founder of, owns equity in, and acts as a consultant for Geras Bio; and holds patents related to senolytics. T.v.Z. is a member of the advisory boards of the Mayo Clinic Robert and Arlene Kogod Center on Aging and of Nuchido.

Funding Information:
We would like to thank Nikolaos Kastrinakis, Panagiotis V.S. Vasileiou, Gkikas Magiorkinis, Eleni Fitsiou, and Michela Borghesan for their valuable support to this work. We apologize in advance that, for reason of space, we have omitted the citations of relevant papers and reviews. M.D. is funded by the Dutch Cancer Foundation , Netherlands (grant ID 10989 ). V.G., K.E., and K.V. were financially supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grants agreement no. 722729 (SYNTRAIN); the Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece; the KIKPE Foundation , Athens, Greece; Pentagon Biotechnology , UK; DeepMed IO , UK; grant no. 775 from the Hellenic Foundation for Research and Innovation (HFRI) ; and NKUA-SARG grants 70/3/9816 , 70/3/12128 , and 70/3/15603 . M.S.: is funded by the IRB and by grants from the Spanish Ministry of Economy co-funded by the European Regional Development Fund (ERDF) ( SAF2013-48256-R ), the European Research Council ( ERC-2014-AdG/669622 ), and “laCaixa” Foundation.

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